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EC 1.3.99.32 Details
EC number
1.3.99.32
Accepted name
glutaryl-CoA dehydrogenase (acceptor)
Reaction
glutaryl-CoA + acceptor = (E)-glutaconyl-CoA + reduced acceptor
Other name(s)
GDHDes, nondecarboxylating glutaryl-coenzyme A dehydrogenase, nondecarboxylating glutaconyl-coenzyme A-forming GDH, glutaryl-CoA dehydrogenase (non-decarboxylating)
Systematic name
glutaryl-CoA:acceptor 2,3-oxidoreductase (non-decarboxylating)
Comment
The enzyme contains FAD. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (EC 1.3.8.6), and a nondecarboxylating enzyme (this entry). The two enzymes cause different structural changes around the glutaconyl carboxylate group, primarily due to the presence of either a tyrosine or a valine residue, respectively, at the active site.
History
created 2012, modified 2013
EC Tree
1.3.99.9 created 1976, deleted 2002