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EC 1.3.1.78 Details
EC number
1.3.1.78
Accepted name
arogenate dehydrogenase (NADP+)
Reaction
L-arogenate + NADP+ = L-tyrosine + NADPH + CO2
Other name(s)
arogenic dehydrogenase (ambiguous), pretyrosine dehydrogenase (ambiguous), TyrAAT1, TyrAAT2, TyrAa
Systematic name
L-arogenate:NADP+ oxidoreductase (decarboxylating)
CAS registry number
64295-75-6
Comment
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NADP+-dependent enzymes usually predominate in higher plants.The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly [2,3].
History
created 2005
EC Tree
1.3.1.23 created 1972, deleted 2005
1.3.1.50 created 1992, deleted 1999
1.3.1.55 created 1999, deleted 2004