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EC 1.3.1.112 Details
EC number
1.3.1.112
Accepted name
anthocyanidin reductase [(2S)-flavan-3-ol-forming]
Reaction
(1) a (2S,3R)-flavan-3-ol + 2 NADP+ = an anthocyanidin with a 3-hydroxy group + 2 NADPH + H+;;(2) a (2S,3S)-flavan-3-ol + 2 NADP+ = an anthocyanidin with a 3-hydroxy group + 2 NADPH + H+
Systematic name
(2S)-flavan-3-ol:NAD(P)+ oxidoreductase
Comment
The enzyme, characterized from Vitis vinifera (grape), participates in the flavonoid biosynthesis pathway. It catalyses the double reduction of anthocyanidins, producing a mixture of (2S,3S)- and (2S,3R)-flavan-3-ols. The enzyme catalyses sequential hydride transfers to C-2 and C-4, respectively. Epimerization at C-3 is achieved by tautomerization that occurs between the two hydride transfers. cf. EC 1.3.1.77, anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming].
History
created 2016
EC Tree
1.3.1.23 created 1972, deleted 2005
1.3.1.50 created 1992, deleted 1999
1.3.1.55 created 1999, deleted 2004