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EC 1.3.1.107 Details
EC number
1.3.1.107
Accepted name
sanguinarine reductase
Reaction
(1) dihydrosanguinarine + NAD(P)+ = sanguinarine + NAD(P)H + H+;;(2) dihydrochelirubine + NAD(P)+ = chelirubine + NAD(P)H + H+
Systematic name
dihydrosanguinarine:NAD(P)+ oxidoreductase
Comment
The enzyme, purified from the California poppy (Eschscholzia californica), is involved in detoxifying the phytoalexin sanguinarine produced by poppy itself (cf. EC 1.5.3.12, dihydrobenzophenanthridine oxidase), when it binds to the cell wall of the poppy cell. The reaction with NADPH is up to three times faster than that with NADH at low concentrations (<10 uM) of the dinucleotide. At higher concentrations the reaction with NADPH is inhibited but not that with NADH [1].
History
created 2014
EC Tree
1.3.1.23 created 1972, deleted 2005
1.3.1.50 created 1992, deleted 1999
1.3.1.55 created 1999, deleted 2004