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EC 1.4.3.22 Details
show Brenda entryEC number
1.4.3.22
Accepted name
diamine oxidase
Reaction
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
Other name(s)
amine oxidase (ambiguous),
amine oxidase (copper-containing) (ambiguous),
CAO (ambiguous),
Cu-containing amine oxidase (ambiguous),
copper amine oxidase (ambiguous),
diamine oxidase (ambiguous),
diamino oxhydrase (ambiguous),
histaminase,
histamine deaminase (incorrect),
semicarbazide-sensitive amine oxidase (incorrect),
SSAO (incorrect)
Systematic name
histamine:oxygen oxidoreductase (deaminating)
Comment
A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 (primary-amine oxidase) but unlike EC 1.4.3.4 (monoamine oxidase), they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide.
History
created 2007 (EC 1.4.3.6 created 1961, part-incorporated 2008)
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.3.9 created 1972, deleted 1984 1.4.3.17 created 2000, deleted 2003 1.4.3.18 proposed 2000
