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EC 1.4.3.21 Details
show Brenda entryEC number
1.4.3.21
Accepted name
primary-amine oxidase
Reaction
RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2
Other name(s)
amine oxidase (ambiguous),
amine oxidase (copper-containing),
amine oxidase (pyridoxal containing) (incorrect),
benzylamine oxidase (incorrect),
CAO (ambiguous),
copper amine oxidase (ambiguous),
Cu-amine oxidase (ambiguous),
Cu-containing amine oxidase (ambiguous),
diamine oxidase (incorrect),
diamino oxhydrase (incorrect),
histamine deaminase (ambiguous),
histamine oxidase (ambiguous),
monoamine oxidase (ambiguous),
plasma monoamine oxidase (ambiguous),
polyamine oxidase (ambiguous),
semicarbazide-sensitive amine oxidase (ambiguous),
SSAO (ambiguous)
Systematic name
primary-amine:oxygen oxidoreductase (deaminating)
Comment
A group of enzymes that oxidize primary monoamines but have little or no activity towards diamines, such as histamine, or towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, monoamine oxidase, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. In some mammalian tissues the enzyme also functions as a vascular-adhesion protein (VAP-1).
History
created 2007 (EC 1.4.3.6 created 1961, part-incorporated 2008)
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.3.9 created 1972, deleted 1984 1.4.3.17 created 2000, deleted 2003 1.4.3.18 proposed 2000
