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EC Details
EC number
Accepted name
L-aspartate oxidase
L-aspartate + O2 = iminosuccinate + H2O2
Other name(s)
NadB, Laspo, AO
Systematic name
L-aspartate:oxygen oxidoreductase
CAS registry number
A flavoprotein (FAD). L-Aspartate oxidase catalyses the first step in the de novo biosynthesis of NAD+ in some bacteria. O2 can be replaced by fumarate as electron acceptor, yielding succinate [5]. The ability of the enzyme to use both O2 and fumarate in cofactor reoxidation enables it to function under both aerobic and anaerobic conditions [5]. Iminosuccinate can either be hydrolysed to form oxaloacetate and NH3 or can be used by EC, quinolinate synthase, in the production of quinolinate. The enzyme is a member of the succinate dehydrogenase/fumarate-reductase family of enzymes [5].
created 1984, modified 2008
EC Tree created 1972, deleted 1984 created 2000, deleted 2003 proposed 2000