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EC Details
EC number
Accepted name
protein-lysine 6-oxidase
[protein]-L-lysine + O2 + H2O = [protein]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
Other name(s)
lysyl oxidase
Systematic name
protein-L-lysine:oxygen 6-oxidoreductase (deaminating)
CAS registry number
Also acts on protein 5-hydroxylysine. This enzyme catalyses the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices [4]. These reactions play an important role for the development, elasticity and extensibility of connective tissue. The enzyme is also active on free amines, such as cadaverine or benzylamine [4,5]. Some isoforms can also use [protein]-N(6)-acetyl-L-lysine as substrate deacetamidating the substrate [6].
created 1980, modified 1983
EC Tree created 1972, deleted 1984 created 2000, deleted 2003 proposed 2000