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EC Details
EC number
Accepted name
pyridoxal 5′-phosphate synthase
(1) pyridoxamine 5′-phosphate + H2O + O2 = pyridoxal 5′-phosphate + NH3 + H2O2;;(2) pyridoxine 5′-phosphate + O2 = pyridoxal 5′-phosphate + H2O2
Other name(s)
pyridoxamine 5′-phosphate oxidase, pyridoxamine phosphate oxidase, pyridoxine (pyridoxamine)phosphate oxidase, pyridoxine (pyridoxamine) 5′-phosphate oxidase, pyridoxaminephosphate oxidase (EC deaminating), PMP oxidase, pyridoxol-5′-phosphate:oxygen oxidoreductase (deaminating) (incorrect), pyridoxamine-phosphate oxidase, PdxH
Systematic name
pyridoxamine-5′-phosphate:oxygen oxidoreductase (deaminating)
CAS registry number
A flavoprotein (FMN). In Escherichia coli, the coenzyme pyridoxal 5′-phosphate is synthesized de novo by a pathway that involves EC (erythrose-4-phosphate dehydrogenase), EC (4-phosphoerythronate dehydrogenase), EC (phosphoserine transaminase), EC (4-hydroxythreonine-4-phosphate dehydrogenase), EC (pyridoxine 5′-phosphate synthase) and EC (with pyridoxine 5′-phosphate as substrate). N4′-Substituted pyridoxamine derivatives are also oxidized in reaction (1) to form pyridoxal 5-phosphate and the corresponding primary amine.
created 1961, modified 2006
EC Tree created 1972, deleted 1984 created 2000, deleted 2003 proposed 2000