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EC Details
EC number
Accepted name
monoamine oxidase
RCH2NHR′ + H2O + O2 = RCHO + R′NH2 + H2O2
Other name(s)
adrenalin oxidase, adrenaline oxidase, amine oxidase (ambiguous), amine oxidase (flavin-containing), amine:oxygen oxidoreductase (deaminating) (flavin-containing), epinephrine oxidase, MAO, MAO A, MAO B, MAO-A, MAO-B, monoamine oxidase A, monoamine oxidase B, monoamine:O2 oxidoreductase (deaminating), polyamine oxidase (ambiguous), serotonin deaminase, spermidine oxidase (ambiguous), spermine oxidase (ambiguous), tyraminase, tyramine oxidase
Systematic name
amine:oxygen oxidoreductase (deaminating)
CAS registry number
A mitochondrial outer-membrane flavoprotein (FAD) that catalyses the oxidative deamination of neurotransmitters and biogenic amines [3]. Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. This enzyme is inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC and EC (diamine oxidase), it is not inhibited by semicarbazide.
created 1961, modified 1983 (EC created 1972, incorporated 1984), modified 2008
EC Tree created 1972, deleted 1984 created 2000, deleted 2003 proposed 2000