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EC 1.4.3.20 Details

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EC number

1.4.3.20

Accepted name

L-lysine 6-oxidase

Reaction

L-lysine + O₂ + H₂O = (S)-2-amino-6-oxohexanoate + H₂O₂ + NH₃

Other name(s)

L-lysine-ε-oxidase, Lod, LodA, marinocine

Systematic name

L-lysine:oxygen 6-oxidoreductase (deaminating)

CAS registry number

1116448-48-6

Comment

Differs from EC 1.4.3.13, protein-lysine 6-oxidase, by using free L-lysine rather than the protein-bound form. N²-Acetyl-L-lysine is also a substrate, but N⁶-acetyl-L-lysine, which has an acetyl group at position 6, is not a substrate. Also acts on L-ornithine, D-lysine and 4-hydroxy-L-lysine, but more slowly. The amines cadaverine and putrescine are not substrates [2].

History

created 2006, modified 2011

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.2 With a cytochrome as acceptor

1.4.3 With oxygen as acceptor

1.4.3.1 D-aspartate oxidase

1.4.3.2 L-amino-acid oxidase

1.4.3.3 D-amino-acid oxidase

1.4.3.4 monoamine oxidase

1.4.3.5 pyridoxal 5′-phosphate synthase

1.4.3.6 amine oxidase (copper-containing)

1.4.3.7 D-glutamate oxidase

1.4.3.8 ethanolamine oxidase

1.4.3.9 created 1972, deleted 1984

1.4.3.10 putrescine oxidase

1.4.3.11 L-glutamate oxidase

1.4.3.12 cyclohexylamine oxidase

1.4.3.13 protein-lysine 6-oxidase

1.4.3.14 L-lysine oxidase

1.4.3.15 D-glutamate(D-aspartate) oxidase

1.4.3.16 L-aspartate oxidase

1.4.3.17 created 2000, deleted 2003

1.4.3.18 proposed 2000

1.4.3.19 glycine oxidase

1.4.3.20 L-lysine 6-oxidase

1.4.3.21 primary-amine oxidase

1.4.3.22 diamine oxidase

1.4.3.23 7-chloro-L-tryptophan oxidase

1.4.3.24 pseudooxynicotine oxidase

1.4.3.25 L-arginine oxidase

1.4.3.26 pre-mycofactocin synthase

1.4.4 With a disulfide as acceptor

1.4.5 With a quinone or other compound as acceptor

1.4.7 With an iron-sulfur protein as acceptor

1.4.9 With a copper protein as acceptor

1.4.98. undefined

1.4.99 With unknown physiological acceptors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.20.1 With NAD⁺ or NADP⁺ as acceptor

1.20.2 With a cytochrome as acceptor

1.20.4 With disulfide as acceptor

1.20.9 With a copper protein as acceptor

1.20.98 With other, known, physiological acceptors

1.20.99 With unknown physiological acceptors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.98.1. undefined

1.99 Other enzymes using O₂ as oxidant (deleted subclass)