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EC 1.4.7.1 Details
show Brenda entryEC number
1.4.7.1
Accepted name
glutamate synthase (ferredoxin)
Reaction
2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+ (overall reaction);;(1a) L-glutamate + NH3 = L-glutamine + H2O;;(1b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+
Other name(s)
ferredoxin-dependent glutamate synthase,
ferredoxin-glutamate synthase,
glutamate synthase (ferredoxin-dependent)
Systematic name
L-glutamate:ferredoxin oxidoreductase (transaminating)
CAS registry number
62213-56-3
Comment
Binds a [3Fe-4S] cluster as well as FAD and FMN. The protein is composed of two domains, one hydrolysing L-glutamine to NH3 and L-glutamate (cf. EC 3.5.1.2, glutaminase), the other combining the produced NH3 with 2-oxoglutarate to produce a second molecule of L-glutamate. The NH3 is channeled through a 24 Å channel in the active protein. No hydrolysis of glutamine takes place without ferredoxin and 2-oxoglutarate being bound to the protein [5,6].
History
created 1976, modified 2012
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.99.1 D-amino-acid dehydrogenase
