EC Explorer
[browse EC tree] - [search]
EC 3.1.4.53 Details
show Brenda entryEC number
3.1.4.53
Accepted name
3′,5′-cyclic-AMP phosphodiesterase
Reaction
adenosine 3′,5′-cyclic phosphate + H2O = AMP
Other name(s)
cAMP-specific phosphodiesterase,
cAMP-specific PDE,
PDE1,
PDE2A,
PDE2B,
PDE4,
PDE7,
PDE8,
PDEB1,
PDEB2
Systematic name
3′,5′-cyclic-AMP 5′-nucleotidohydrolase
Comment
Requires Mg2+ or Mn2+ for activity [2]. This enzyme is specific for 3′,5′-cAMP and does not hydrolyse other nucleoside 3′,5′-cyclic phosphates such as cGMP (cf. EC 3.1.4.17, 3,5-cyclic-nucleotide phosphodiesterase and EC 3.1.4.35, 3,5-cyclic-GMP phosphodiesterase). It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation [3].
History
created 2008, modified 2011
back to topEC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.3.9 created 1972, deleted 1984 1.4.3.17 created 2000, deleted 2003 1.4.3.18 proposed 2000
