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EC 5.5.1.16 Details

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EC number

5.5.1.16

Accepted name

halimadienyl-diphosphate synthase

Reaction

geranylgeranyl diphosphate = tuberculosinyl diphosphate

Other name(s)

Rv3377c, halimadienyl diphosphate synthase, tuberculosinol diphosphate synthase, halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing), halima-5,13-dien-15-yl-diphosphate lyase (decyclizing)

Systematic name

halima-5,13-dien-15-yl-diphosphate lyase (ring-opening)

Comment

Requires Mg²⁺ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol (halima-5,13-dien-15-ol).

History

created 2008, modified 2012

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.2 With a cytochrome as acceptor

1.4.3 With oxygen as acceptor

1.4.3.1 D-aspartate oxidase

1.4.3.2 L-amino-acid oxidase

1.4.3.3 D-amino-acid oxidase

1.4.3.4 monoamine oxidase

1.4.3.5 pyridoxal 5′-phosphate synthase

1.4.3.6 amine oxidase (copper-containing)

1.4.3.7 D-glutamate oxidase

1.4.3.8 ethanolamine oxidase

1.4.3.9 created 1972, deleted 1984

1.4.3.10 putrescine oxidase

1.4.3.11 L-glutamate oxidase

1.4.3.12 cyclohexylamine oxidase

1.4.3.13 protein-lysine 6-oxidase

1.4.3.14 L-lysine oxidase

1.4.3.15 D-glutamate(D-aspartate) oxidase

1.4.3.16 L-aspartate oxidase

1.4.3.17 created 2000, deleted 2003

1.4.3.18 proposed 2000

1.4.3.19 glycine oxidase

1.4.3.20 L-lysine 6-oxidase

1.4.3.21 primary-amine oxidase

1.4.3.22 diamine oxidase

1.4.3.23 7-chloro-L-tryptophan oxidase

1.4.3.24 pseudooxynicotine oxidase

1.4.3.25 L-arginine oxidase

1.4.3.26 pre-mycofactocin synthase

1.4.4 With a disulfide as acceptor

1.4.5 With a quinone or other compound as acceptor

1.4.7 With an iron-sulfur protein as acceptor

1.4.9 With a copper protein as acceptor

1.4.98. undefined

1.4.99 With unknown physiological acceptors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)