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EC 3.4.21.116 Details
EC number
3.4.21.116
Accepted name
SpoIVB peptidase
Reaction
Self-cleaves Val52┼Asn53, Ala62┼Phe63 and Val74┼Thr75 at the N-terminus of SpoIVB
Other name(s)
sporulation factor IV B protease
CAS registry number
296241-18-4
Comment
This enzyme plays a central role in a regulatory checkpoint (the σK checkpoint), which coordinates gene expression during the later stages of spore formation in Bacillus subtilis [1,3]. The enzyme activates proteolytic processing of a sporulation-specific sigma factor, pro-σK, to its mature and active form, σK, by self-cleavage [1,3]. The enzyme is also subject to secondary proteolysis, which presumably inactivates SpoIVB [3]. The enzyme is also essential for the formation of heat-resistant spores. Belongs in peptidase family S55.
History
created 2006
EC Tree
1.4.3.9 created 1972, deleted 1984
1.4.3.17 created 2000, deleted 2003
1.4.3.18 proposed 2000