Any feedback?
Please rate this page

BRENDA support

EC Explorer

EC Details
EC number
Accepted name
lysine 6-dehydrogenase
L-lysine + NAD+ = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NADH + H+ + NH3 (overall reaction);;(1a) L-lysine + NAD+ + H2O = (S)-2-amino-6-oxohexanoate + NADH + H+ + NH3;;(1b) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous)
Other name(s)
L-lysine ε-dehydrogenase, L-lysine 6-dehydrogenase, LysDH
Systematic name
L-lysine:NAD+ 6-oxidoreductase (deaminating)
CAS registry number
The enzyme is highly specific for L-lysine as substrate, although S-(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly. While the enzyme from Agrobacterium tumefaciens can use only NAD+, that from the thermophilic bacterium Geobacillus stearothermophilus can also use NADP+, but more slowly [1,4].
created 1989, modified 2006, modified 2011
EC Tree created 1961, deleted 1982