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EC Details
EC number
Accepted name
glutamate synthase (NADH)
2 L-glutamate + NAD+ = L-glutamine + 2-oxoglutarate + NADH + H+;;(1a) L-glutamate + NH3 = L-glutamine + H2O;;(1b) L-glutamate + NAD+ + H2O = NH3 + 2-oxoglutarate + NADH + H+
Other name(s)
glutamate (reduced nicotinamide adenine dinucleotide) synthase, NADH: GOGAT, L-glutamate synthase (NADH), L-glutamate synthetase, NADH-glutamate synthase, NADH-dependent glutamate synthase
Systematic name
L-glutamate:NAD+ oxidoreductase (transaminating)
CAS registry number
A flavoprotein (FMN). The reaction takes place in the direction of L-glutamate production. The protein is composed of two domains, one hydrolysing L-glutamine to NH3 and L-glutamate (cf. EC, glutaminase), the other combining the produced NH3 with 2-oxoglutarate to produce a second molecule of L-glutamate (cf. EC, glutamate dehydrogenase).
created 1978, modified 2019
EC Tree created 1961, deleted 1982