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EC Details
EC number
Accepted name
secondary-alkyl amine dehydrogenase [NAD(P)+]
a secondary-alkyl amine + H2O + NAD(P)+ = a ketone + NH3 + NAD(P)H + H+
Other name(s)
AmDH (ambiguous), amine dehydrogenase (ambiguous)
Systematic name
secondary-alkyl amine:NAD(P)+ oxidoreductase (deaminating)
The enzyme has been shown to react preferentially with short-chain ketones such as cyclohexanone, primary amine groups attached to secondary alkyl groups, or D- and L-amino acids. It also reduces aldehydes to primary amines. Cosubstrate preference depends on the substrate.
created 2022
EC Tree created 1961, deleted 1982