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EC 1.1.1.302 Details
show Brenda entryEC number
1.1.1.302
Accepted name
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5′-phosphate reductase
Reaction
2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H + H+
Other name(s)
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5′-phosphate reductase,
MjaRED,
MJ0671 (gene name)
Systematic name
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one:NAD(P)+ oxidoreductase
Comment
The reaction proceeds in the opposite direction. A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant. Differs from EC 1.1.1.193 [5-amino-6-(5-phosphoribosylamino)uracil reductase] since it does not catalyse the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5′-phosphate [1].
History
created 2010, modified 2011
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.4.5.1 D-amino acid dehydrogenase (quinone)
