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EC 1.2.3.6 Details

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EC number

1.2.3.6

Accepted name

pyruvate oxidase (CoA-acetylating)

Reaction

pyruvate + CoA + O₂ = acetyl-CoA + CO₂ + H₂O₂

Systematic name

pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)

CAS registry number

62213-57-4

Comment

A flavoprotein (FAD). May be identical with EC 1.2.7.1 pyruvate synthase.

History

created 1976

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.2 With a cytochrome as acceptor

1.1.3 With oxygen as acceptor

1.1.4 With a disulfide as acceptor

1.1.5 With a quinone or similar compound as acceptor

1.1.7 With an iron-sulfur protein as acceptor

1.1.9 With a copper protein as acceptor

1.1.98 With other, known, physiological acceptors

1.1.99 With unknown physiological acceptors

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.2 With a cytochrome as acceptor

1.2.3 With oxygen as acceptor

1.2.3.1 aldehyde oxidase

1.2.3.2 created 1961, deleted 1984

1.2.3.3 pyruvate oxidase

1.2.3.4 oxalate oxidase

1.2.3.5 glyoxylate oxidase

1.2.3.6 pyruvate oxidase (CoA-acetylating)

1.2.3.7 indole-3-acetaldehyde oxidase

1.2.3.8 pyridoxal oxidase

1.2.3.9 aryl-aldehyde oxidase

1.2.3.10 created 1990, deleted 2003

1.2.3.11 retinal oxidase

1.2.3.12 created 2000, deleted 2003

1.2.3.13 4-hydroxyphenylpyruvate oxidase

1.2.3.14 abscisic-aldehyde oxidase

1.2.3.15 (methyl)glyoxal oxidase

1.2.4 With a disulfide as acceptor

1.2.5 With a quinone or similar compound as acceptor

1.2.7 With an iron-sulfur protein as acceptor

1.2.98 With other, known, physiological acceptors

1.2.99 With unknown physiological acceptors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

5.1 Racemases and epimerases

5.2 cis-trans-Isomerases

5.3 Intramolecular oxidoreductases

5.4 Intramolecular transferases

5.5 Intramolecular lyases

5.6 Isomerases altering macromolecular conformation

5.99 Other isomerases

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Release 2023.1 (January 2023)