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EC 1.2.3.3 Details
EC number
1.2.3.3
Accepted name
pyruvate oxidase
Reaction
pyruvate + phosphate + O2 = acetyl phosphate + CO2 + H2O2
Other name(s)
pyruvic oxidase, phosphate-dependent pyruvate oxidase
Systematic name
pyruvate:oxygen 2-oxidoreductase (phosphorylating)
CAS registry number
9001-96-1
Comment
A flavoprotein (FAD) requiring thiamine diphosphate. Two reducing equivalents are transferred from the resonant carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate (AcThDP) and reduced flavin. FADH2 is reoxidized by O2 to yield H2O2 and FAD and AcThDP is cleaved phosphorolytically to acetyl phosphate and thiamine diphosphate [2].
History
created 1961
EC Tree
1.2.3.2 created 1961, deleted 1984
1.2.3.10 created 1990, deleted 2003
1.2.3.12 created 2000, deleted 2003