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EC 1.2.1.84 Details
EC number
1.2.1.84
Accepted name
alcohol-forming fatty acyl-CoA reductase
Reaction
a long-chain acyl-CoA + 2 NADPH + 2 H+ = a long-chain alcohol + 2 NADP+ + CoA
Other name(s)
FAR (gene name), long-chain acyl-CoA:NADPH reductase
Systematic name
NADPH:long-chain acyl-CoA reductase
Comment
The enzyme has been characterized from the plant Simmondsia chinensis (jojoba). The alcohol is formed by a four-electron reduction of fatty acyl-CoA. Although the reaction proceeds through an aldehyde intermediate, a free aldehyde is not released. The recombinant enzyme was shown to accept saturated and mono-unsaturated fatty acyl-CoAs of 16 to 22 carbons.
History
created 2012
EC Tree
1.2.1.1 created 1961, modified 1982, modified 2002, deleted 2005
1.2.1.6 created 1961, deleted 1965
1.2.1.14 created 1961, deleted 1984
1.2.1.34 created 1972, deleted 1983 [transferred to EC 1.1.1.180, deleted 1984]
1.2.1.35 created 1972, deleted 1984
1.2.1.37 created 1972, deleted 1984
1.2.1.55 created 1990, deleted 2003
1.2.1.56 created 1990, deleted 2003