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EC 1.1.2.8 Details
EC number
1.1.2.8
Accepted name
alcohol dehydrogenase (cytochrome c)
Reaction
a primary alcohol + 2 ferricytochrome c = an aldehyde + 2 ferrocytochrome c + 2 H+
Other name(s)
type I quinoprotein alcohol dehydrogenase, quinoprotein ethanol dehydrogenase
Systematic name
alcohol:cytochrome c oxidoreductase
Comment
A periplasmic PQQ-containing quinoprotein. Occurs in Pseudomonas and Rhodopseudomonas. The enzyme from Pseudomonas aeruginosa uses a specific inducible cytochrome c550 as electron acceptor. Acts on a wide range of primary and secondary alcohols, but not methanol. It has a homodimeric structure [contrasting with the heterotetrameric structure of EC 1.1.2.7, methanol dehydrogenase (cytochrome c)]. It is routinely assayed with phenazine methosulfate as electron acceptor. Activity is stimulated by ammonia or amines. Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed ’propeller’ structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ.
History
created 1972 as EC 1.1.99.8, modified 1982, part transferred 2010 to EC 1.1.2.8
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