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EC 1.1.2.7 Details
EC number
1.1.2.7
Accepted name
methanol dehydrogenase (cytochrome c)
Reaction
a primary alcohol + 2 ferricytochrome cL = an aldehyde + 2 ferrocytochrome cL + 2 H+
Other name(s)
methanol dehydrogenase, MDH (ambiguous)
Systematic name
methanol:cytochrome c oxidoreductase
CAS registry number
37205-43-9
Comment
A periplasmic quinoprotein alcohol dehydrogenase that only occurs in methylotrophic bacteria. It uses the novel specific cytochrome cL as acceptor. Acts on a wide range of primary alcohols, including ethanol, duodecanol, chloroethanol, cinnamyl alcohol, and also formaldehyde. Activity is stimulated by ammonia or methylamine. It is usually assayed with phenazine methosulfate. Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed ’propeller’ structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ. It differs from EC 1.1.2.8, alcohol dehydrogenase (cytochrome c), in having a high affinity for methanol and in having a second essential small subunit (no known function).
History
created 1972 as EC 1.1.99.8, modified 1982, part transferred 2010 to EC 1.1.2.7
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