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EC 1.1.99.30 Details
show Brenda entryEC number
1.1.99.30
Accepted name
2-oxo-acid reductase
Reaction
a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor
Other name(s)
(2R)-hydroxycarboxylate-viologen-oxidoreductase,
HVOR,
2-oxoacid reductase
Systematic name
(2R)-hydroxy-carboxylate:acceptor oxidoreductase
CAS registry number
115299-99-5
Comment
Contains [4Fe-4S] and a mononucleotide molybdenum (pyranopterin) cofactor. Has broad substrate specificity, with 2-oxo-monocarboxylates and 2-oxo-dicarboxylates acting as substrates. Branching in a substrate at the C-3 position results in loss of activity. The enzyme from Proteus sp. is inactivated by oxygen.
History
created 2004
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003
