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EC 1.1.99.27 Details
EC number
1.1.99.27
Accepted name
(R)-pantolactone dehydrogenase (flavin)
Reaction
(R)-pantolactone + acceptor = 2-dehydropantolactone + reduced acceptor
Other name(s)
2-dehydropantolactone reductase (flavin), 2-dehydropantoyl-lactone reductase (flavin), (R)-pantoyllactone dehydrogenase (flavin)
Systematic name
(R)-pantolactone:acceptor oxidoreductase (flavin-containing)
CAS registry number
140879-14-7
Comment
High specificity for (R)-pantolactone. Phenazine methosulfate (PMS) can act as acceptor. The enzyme has been studied in the bacterium Nocardia asteroides and shown to be membrane-bound and induced by 1,2-propanediol. The FMN cofactor is non-covalently bound.
History
created 1999
EC Tree
1.1.99.15 created 1978, deleted 1980
1.1.99.17 created 1982, deleted 2003