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EC 1.1.98.1 Details
EC number
1.1.98.1
Accepted name
alcohol dehydrogenase (azurin)
Reaction
a primary alcohol + oxidized azurin = an aldehyde + reduced azurin
Other name(s)
type II quinoprotein alcohol dehydrogenase, quinohaemoprotein ethanol dehydrogenase, QHEDH, ADHIIB
Systematic name
alcohol:azurin oxidoreductase
Comment
A soluble, periplasmic PQQ-containing quinohemoprotein. Also contains a single heme c. Occurs in Comamonas and Pseudomonas. Does not require an amine activator. Oxidizes a wide range of primary and secondary alcohols, and also aldehydes and large substrates such as sterols; methanol is not a substrate. Usually assayed with phenazine methosulphate or ferricyanide. Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed 'propeller' structure, a calcium ion bound to the PQQ in the active site and an unusual disulphide ring structure in close proximity to the PQQ.
History
created 2010, deleted 2011
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