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EC 1.1.1.334 Details
show Brenda entryEC number
1.1.1.334
Accepted name
methylecgonone reductase
Reaction
ecgonine methyl ester + NADP+ = ecgonone methyl ester + NADPH + H+
Other name(s)
MecgoR (gene name)
Systematic name
ecgonine methyl ester:NADP+ oxidoreductase
Comment
The enzyme from the plant Erythroxylum coca catalyses the penultimate step in the biosynthesis of cocaine. In vivo the reaction proceeds in the opposite direction. With NADH instead of NADPH the reaction rate is reduced to 14%. The enzyme also reduces tropinone, nortropinone and 6-hydroxytropinone but with lower reaction rates.
History
created 2012
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.1.99.15 created 1978, deleted 1980 1.1.99.17 created 1982, deleted 2003
