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EC 6.1.2.1 Details
EC number
6.1.2.1
Accepted name
D-alanine—(R)-lactate ligase
Reaction
D-alanine + (R)-lactate + ATP = D-alanyl-(R)-lactate + ADP + phosphate
Other name(s)
VanA, VanB, VanD
Systematic name
D-alanine:(R)-lactate ligase (ADP-forming)
Comment
The product of this enzyme, the depsipeptide D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine—D-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
History
created 2010
EC Tree
1.1.5.1 created 1983, deleted 2002