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EC 4.2.1.170 Details
EC number
4.2.1.170
Accepted name
2-(ω-methylthio)alkylmalate dehydratase
Reaction
(1) a 2-[(ω-methylsulfanyl)alkyl]malate = a 2-[(ω-methylsulfanyl)alkyl]maleate + H2O;;(2) a 3-[(ω-methylsulfanyl)alkyl]malate = a 2-[(ω-methylsulfanyl)alkyl]maleate + H2O
Other name(s)
IPMI (gene name), 2-[(ω-methylthio)alkyl]malate hydro-lyase (2-[(ω-methylthio)alkyl]maleate-forming)
Systematic name
2-[(ω-methylsulfanyl)alkyl]malate hydro-lyase (2-[(ω-methylsulfanyl)alkyl]maleate-forming)
Comment
The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates. By catalysing a dehydration of a 2-[(ω-methylsulfanyl)alkyl]maleate, followed by a hydration at a different position, the enzyme achieves the isomerization of its substrates. The enzyme is a heterodimer comprising a large and a small subunits. The large subunit can also bind to an alternative small subunit, forming EC 4.2.1.33, 3-isopropylmalate dehydratase, which participates in L-leucine biosynthesis.
History
created 2016
EC Tree
1.1.1.68 created 1965, deleted 1978 [transferred to EC 1.1.99.15, deleted 1980]
1.1.1.70 created 1965, deleted 1978
1.1.1.74 created 1972, deleted 1976
1.1.1.89 created 1972, deleted 1976
1.1.1.109 created 1972, deleted 1976
1.1.1.139 created 1972, deleted 1978
1.1.1.155 created 1976, deleted 2004
1.1.1.171 created 1978, deleted 1984
1.1.1.180 created 1983, deleted 1984
1.1.1.182 created 1983, deleted 1990
1.1.1.204 created 1972 as EC 1.2.1.37, transferred 1984 to EC 1.1.1.204, modified 1989, deleted 2004
1.1.1.242 created 1992, deleted 2001
1.1.1.249 provisional version created 1999, deleted 1999 (reinstated 2001 as EC 2.5.1.46)
1.1.1.253 created 1999, deleted 2003