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EC 1.1.1.337 Details
show Brenda entryEC number
1.1.1.337
Accepted name
L-2-hydroxycarboxylate dehydrogenase (NAD+)
Reaction
a (2S)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+
Other name(s)
(R)-sulfolactate:NAD+ oxidoreductase,
L-sulfolactate dehydrogenase,
(R)-sulfolactate dehydrogenase,
L-2-hydroxyacid dehydrogenase (NAD+),
ComC
Systematic name
(2S)-2-hydroxycarboxylate:NAD+ oxidoreductase
CAS registry number
81210-65-3
Comment
The enzyme from the archaeon Methanocaldococcus jannaschii acts on multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate [3]. Note that (2R)-3-sulfolactate has the same stereo configuration as (2S)-2-hydroxycarboxylates.
History
created 2012
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1 Oxidoreductases
1.1.1.70 created 1965, deleted 1978 1.1.1.74 created 1972, deleted 1976 1.1.1.89 created 1972, deleted 1976 1.1.1.109 created 1972, deleted 1976 1.1.1.139 created 1972, deleted 1978 1.1.1.155 created 1976, deleted 2004 1.1.1.171 created 1978, deleted 1984 1.1.1.180 created 1983, deleted 1984 1.1.1.182 created 1983, deleted 1990 1.1.1.204 created 1972 as EC 1.2.1.37, transferred 1984 to EC 1.1.1.204, modified 1989, deleted 2004 1.1.1.242 created 1992, deleted 2001 1.1.1.253 created 1999, deleted 2003
1.1.2 With a cytochrome as acceptor
