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EC 1.2.7.12 Details
EC number
1.2.7.12
Accepted name
formylmethanofuran dehydrogenase
Reaction
a formylmethanofuran + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster = CO2 + a methanofuran + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+
Other name(s)
formylmethanofuran:acceptor oxidoreductase
Systematic name
formylmethanofuran:ferredoxin oxidoreductase
CAS registry number
119940-12-4
Comment
Contains a molybdopterin cofactor and numerous [4Fe-4S] clusters. In some organisms an additional subunit enables the incorporation of tungsten when molybdenum availability is low. The enzyme catalyses a reversible reaction in methanogenic archaea, and is involved in methanogenesis from CO2 as well as the oxidation of coenzyme M to CO2. The reaction is endergonic, and is driven by coupling with the soluble CoB-CoM heterodisulfide reductase via electron bifurcation.
History
created 1992 as EC 1.2.99.5, transferred 2017 to EC 1.2.7.12
EC Tree
1.2.7.9 created 2003, deleted 2005