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EC 1.2.7.7 Details
show Brenda entryEC number
1.2.7.7
Accepted name
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
Reaction
3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+
Other name(s)
2-ketoisovalerate ferredoxin reductase,
3-methyl-2-oxobutanoate synthase (ferredoxin),
VOR,
branched-chain ketoacid ferredoxin reductase,
branched-chain oxo acid ferredoxin reductase,
keto-valine-ferredoxin oxidoreductase,
ketoisovalerate ferredoxin reductase,
2-oxoisovalerate ferredoxin reductase
Systematic name
3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)
Comment
The enzyme is CoA-dependent and contains thiamine diphosphate and iron-sulfur clusters. Preferentially utilizes 2-oxo-acid derivatives of branched chain amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo-pentanoate, and 2-oxobutanoate. This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that reversibly catalyse the oxidative decarboxylation of different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. For examples of other members of this family, see EC 1.2.7.1, pyruvate synthase, and EC 1.2.7.3, 2-oxoglutarate synthase.
History
created 2003
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.2.7.9 created 2003, deleted 2005
