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EC 1.20.4.4 Details
EC number
1.20.4.4
Accepted name
arsenate reductase (thioredoxin)
Reaction
arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O
Other name(s)
ArsC (ambiguous)
Systematic name
arsenate:thioredoxin oxidoreductase
Comment
The enzyme, characterized in bacteria of the Firmicutes phylum, is specific for thioredoxin [1]. It has no activity with glutaredoxin [cf. EC 1.20.4.1, arsenate reductase (glutaredoxin)]. Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7, arsenite-transporting ATPase; in other organisms, arsenite can be methylated by EC 2.1.1.137, arsenite methyltransferase, in a pathway that produces non-toxic organoarsenical compounds. The enzyme also has the activity of EC 3.1.3.48, protein-tyrosine-phosphatase [3].
History
created 2015, modified 2019
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