EC Explorer

1.17.1.9

formate dehydrogenase

formate + NAD⁺ = CO₂ + NADH

formate-NAD⁺ oxidoreductase, FDH I, FDH II, N-FDH, formic hydrogen-lyase, formate hydrogenlyase, hydrogenlyase, NAD⁺-linked formate dehydrogenase, NAD⁺-dependent formate dehydrogenase, formate dehydrogenase (NAD⁺), NAD⁺-formate dehydrogenase, formate benzyl-viologen oxidoreductase, formic acid dehydrogenase

formate:NAD⁺ oxidoreductase

9028-85-7

The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre [3]. Together with EC 1.12.1.2 hydrogen dehydrogenase, forms a system previously known as formate hydrogenlyase.

created 1961 as EC 1.2.1.2, transferred 2017 to EC 1.17.1.9