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EC 1.17.1.2 Details
show Brenda entryEC number
1.17.1.2
Accepted name
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Reaction
(1) isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+;;(2) dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
Other name(s)
isopentenyl-diphosphate:NADP+ oxidoreductase,
LytB,
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase,
HMBPP reductase,
IspH,
LytB/IspH
Systematic name
isopentenyl-diphosphate:NAD(P)+ oxidoreductase
CAS registry number
512789-14-9
Comment
An iron-sulfur protein that contains either a [3Fe-4S] [6] or a [4Fe-4S] [5] cluster. This enzyme comprises a system in which ferredoxin is first reduced and subsequently reoxidized by an NAD(P)+-dependent reductase. This is the last enzyme in the non-mevalonate pathway for isoprenoid biosynthesis. This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most bacteria and in plant chloroplasts. The enzyme acts in the reverse direction, producing a 5:1 mixture of isopentenyl diphosphate and dimethylallyl diphosphate.
History
created 2003, modified 2009, deleted 2016
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.99.4 created 1965, deleted 1972 1.6.99.8 created 1972, deleted 2002 1.6.99.9 created 1972, deleted 2002 1.6.99.10 created 1978, deleted 1981 1.6.99.11 created 1989, deleted 2002 1.6.99.12 created 1989, deleted 2002 1.6.99.13 created 1992, deleted 2002
