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EC 1.6.3.5 Details
EC number
1.6.3.5
Accepted name
renalase
Reaction
(1) 1,2-dihydro-β-NAD(P) + H+ + O2 = β-NAD(P)+ + H2O2;;(2) 1,6-dihydro-β-NAD(P) + H+ + O2 = β-NAD(P)+ + H2O2
Other name(s)
αNAD(P)H oxidase/anomerase (incorrect), NAD(P)H:oxygen oxidoreductase (H2O2-forming, epimerising) (incorrect)
Systematic name
dihydro-NAD(P):oxygen oxidoreductase (H2O2-forming)
Comment
Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of β-NAD(P)H back to β-NAD(P)+. These isomeric forms, generated by nonspecific reduction of β-NAD(P)+ or by tautomerization of β-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.
History
created 2014, modified 2015
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