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EC 2.3.3.5 Details
EC number
2.3.3.5
Accepted name
2-methylcitrate synthase
Reaction
propanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
Other name(s)
2-methylcitrate oxaloacetate-lyase, MCS, methylcitrate synthase, methylcitrate synthetase
Systematic name
propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)
CAS registry number
57827-78-8
Comment
The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC 2.3.3.1, citrate (Si)-synthase. Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate.
History
created 1978 as EC 4.1.3.31, transferred 2002 to EC 2.3.3.5, modified 2015
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