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EC 2.3.2.22 Details
EC number
2.3.2.22
Accepted name
cyclo(L-leucyl-L-leucyl) synthase
Reaction
2 L-leucyl-tRNALeu = 2 tRNALeu + cyclo(L-leucyl-L-leucyl)
Other name(s)
YvmC, cLL synthase, cyclodileucine synthase
Systematic name
L-leucyl-tRNALeu:L-leucyl-tRNALeu leucyltransferase (cyclizing)
Comment
The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-leucine residue [2]. The proteins from bacteria of the genus Bacillus also form small amounts of cyclo(L-phenylalanyl-L-leucyl) and cyclo(L-leucyl-L-methionyl) [1].
History
created 2013
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