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EC 2.3.2.21 Details
EC number
2.3.2.21
Accepted name
cyclo(L-tyrosyl-L-tyrosyl) synthase
Reaction
2 L-tyrosyl-tRNATyr = 2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl)
Other name(s)
Rv2275 (gene name), cYY synthase, cyclodityrosine synthase
Systematic name
L-tyrosyl-tRNATyr:L-tyrosyl-tRNATyr tyrosyltransferase (cyclizing)
Comment
The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue [2]. The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl) [1].
History
created 2013
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