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EC 2.3.2.13 Details
EC number
2.3.2.13
Accepted name
protein-glutamine γ-glutamyltransferase
Reaction
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3
Other name(s)
transglutaminase,
Factor XIIIa,
fibrinoligase,
fibrin stabilizing factor,
glutaminylpeptide γ-glutamyltransferase,
polyamine transglutaminase,
tissue transglutaminase,
R-glutaminyl-peptide:amine γ-glutamyl transferase
Systematic name
protein-glutamine:amine γ-glutamyltransferase
CAS registry number
80146-85-6
Comment
Requires Ca2+. The γ-carboxamide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N6-(5-glutamyl)-lysine crosslinks. Formed by proteolytic cleavage from plasma Factor XIII
History
created 1978, modified 1981, modified 1983
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