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EC 2.3.2.6 Details
EC number
2.3.2.6
Accepted name
lysine/arginine leucyltransferase
Reaction
(1) L-leucyl-tRNALeu + N-terminal L-lysyl-[protein] = tRNALeu + N-terminal L-leucyl-L-lysyl-[protein] ;;(2) L-leucyl-tRNALeu + N-terminal L-arginyl-[protein] = tRNALeu + N-terminal L-leucyl-L-arginyl-[protein]
Other name(s)
leucyl, phenylalanine-tRNA-protein transferase,
leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase,
leucyl-phenylalanine-transfer ribonucleate-protein transferase,
L-leucyl-tRNA:protein leucyltransferase,
leucyltransferase (misleading),
L/FK,R-transferase,
aat (gene name),
L-leucyl-tRNALeu:protein leucyltransferase
Systematic name
L-leucyl-tRNALeu:[protein] N-terminal L-lysine/L-arginine leucyltransferase
CAS registry number
37257-22-0
Comment
Requires a univalent cation. The enzyme participates in the N-end rule protein degradation pathway in certain bacteria, by attaching the primary destabilizing residue L-leucine to the N-termini of proteins that have an N-terminal L-arginine or L-lysine residue. Once modified, the proteins are recognized by EC 3.4.21.92, the ClpAP/ClpS endopeptidase system. The enzyme also transfers L-phenylalanine in vitro, but this has not been observed in vivo [5]. cf. EC 2.3.2.29, aspartate/glutamate leucyltransferase, and EC 2.3.2.8, arginyltransferase.
History
created 1972, modified 1976, modified 2013, modified 2016
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