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EC Details
EC number
Accepted name
bile-acid 7α-dehydroxylase
(1) deoxycholate + NAD+ + H2O = cholate + NADH + H+;;(2) lithocholate + NAD+ + H2O = chenodeoxycholate + NADH + H+
Other name(s)
cholate 7α-dehydroxylase, 7α-dehydroxylase, bile acid 7-dehydroxylase
Systematic name
deoxycholate:NAD+ oxidoreductase
This enzyme is highly specific for bile-acid substrates and requires a free C-24 carboxy group and an unhindered 7α-hydroxy group on the B-ring of the steroid nucleus for activity. May be regulated by the ratio of NAD+ to NADH [2].
created 2005, deleted 2006
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