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EC Details
EC number
Accepted name
nicotinate dehydrogenase
nicotinate + H2O + NADP+ = 6-hydroxynicotinate + NADPH + H+
Other name(s)
nicotinic acid hydroxylase, nicotinate hydroxylase
Systematic name
nicotinate:NADP+ 6-oxidoreductase (hydroxylating)
CAS registry number
A flavoprotein containing non-heme iron. The enzyme is capable of acting on a variety of nicotinate analogues to varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3-dicarboxylate, trigonelline and 6-methylnicotinate. The enzyme from Clostridium barkeri also possesses a catalytically essential, labile selenium that can be removed by reaction with cyanide.
created 1972 as EC, transferred 2004 to EC
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