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EC Details
EC number
Accepted name
arsenate reductase (thioredoxin)
arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O
Other name(s)
ArsC (ambiguous)
Systematic name
arsenate:thioredoxin oxidoreductase
The enzyme, characterized in bacteria of the Firmicutes phylum, is specific for thioredoxin [1]. It has no activity with glutaredoxin [cf. EC, arsenate reductase (glutaredoxin)]. Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC, arsenite-transporting ATPase; in other organisms, arsenite can be methylated by EC, arsenite methyltransferase, in a pathway that produces non-toxic organoarsenical compounds. The enzyme also has the activity of EC, protein-tyrosine-phosphatase [3].
created 2015, modified 2019
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