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EC 1.14.99.68 Details
EC number
1.14.99.68
Accepted name
4-aminobenzoate N-oxygenase
Reaction
4-aminobenzoate + reduced acceptor + 2 O2 = 4-nitrobenzoate + acceptor + 2 H2O
Other name(s)
aurF (gene name)
Systematic name
4-aminobenzoate,acceptor:oxygen oxidoreductase (N-hydroxylating)
Comment
The enzyme, characterized from the bacterium Streptomyces thioluteus, catalyses an early step in the biosynthesis of the antibiotic aureothin. It contains a carboxylate-bridged binuclear non-heme iron cluster. The native electron donor has not been identified, but is likely an iron-sulfur protein. The reaction mechanism involves formation of an extremely stable peroxo intermediate that catalyses three two-electron oxidations via a hydroxylamine and dihydroxylamine intermediates. cf. EC 1.14.99.67, N-[1-(4-aminophenyl)-1,3-dihydroxypropan-2-yl]-2,2-dichloroacetamide N-oxygenase.
History
created 2020
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