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EC 1.17.7.1 Details
EC number
1.17.7.1
Accepted name
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)
Reaction
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin
Other name(s)
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ambiguous), (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating) (incorrect), (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (ambiguous), gcpE (gene name), ISPG (gene name), (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase
Systematic name
(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductase
Comment
An iron-sulfur protein found in plant chloroplasts and cyanobacteria that contains a [4Fe-4S] cluster [1]. Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis. Bacteria have a similar enzyme that uses flavodoxin rather than ferredoxin (cf. EC 1.17.7.3). The enzyme from the plant Arabidopsis thaliana is active with photoreduced 5-deazaflavin but not with flavodoxin [1].
History
created 2003 as EC 1.17.4.3, transferred 2009 to EC 1.17.7.1, modified 2014
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