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EC 1.16.1.3 Details

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EC number

1.16.1.3

Accepted name

aquacobalamin reductase

Reaction

2 cob(II)alamin + NAD⁺ + 2 H₂O = 2 aquacob(III)alamin + NADH + H⁺

Other name(s)

aquocobalamin reductase, vitamin B_12a reductase, NADH-linked aquacobalamin reductase, B_12a reductase, NADH₂:cob(III)alamin oxidoreductase

Systematic name

cob(II)alamin:NAD⁺ oxidoreductase

CAS registry number

37256-39-6

Comment

A flavoprotein.

History

created 1972 as EC 1.6.99.8, transferred 2002 to EC 1.16.1.3, modified 2020, deleted 2020

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.12.1 With NAD⁺ or NADP⁺ as acceptor

1.12.2 With a cytochrome as acceptor

1.12.5 With a quinone or similar compound as acceptor

1.12.7 With an iron-sulfur protein as acceptor

1.12.98 With other, known, physiological acceptors

1.12.99 With unknown physiological acceptors

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.16.1 With NAD⁺ or NADP⁺ as acceptor

1.16.1.1 mercury(II) reductase

1.16.1.2 diferric-transferrin reductase

1.16.1.3 aquacobalamin reductase

1.16.1.4 cob(II)alamin reductase

1.16.1.5 aquacobalamin reductase (NADPH)

1.16.1.6 cyanocobalamin reductase

1.16.1.7 ferric-chelate reductase (NADH)

1.16.1.8 [methionine synthase] reductase

1.16.1.9 ferric-chelate reductase (NADPH)

1.16.1.10 ferric-chelate reductase [NAD(P)H]

1.16.3 With oxygen as acceptor

1.16.5 With a quinone or similar compound as acceptor

1.16.8 With a flavin as acceptor

1.16.9 With a copper protein as acceptor

1.16.98 With other, known, physiological acceptors

1.16.99 With unknown physiological acceptors

1.17 Acting on CH or CH₂ groups

1.17.1 With NAD⁺ or NADP⁺ as acceptor

1.17.2 With a cytochrome as acceptor

1.17.3 With oxygen as acceptor

1.17.4 With a disulfide as acceptor

1.17.5 With a quinone or similar compound as acceptor

1.17.7 With an iron-sulfur protein as acceptor

1.17.8 With a flavin as acceptor

1.17.9 With a copper protein as acceptor

1.17.98 With other, known, physiological acceptors

1.17.99 With unknown physiological acceptors

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)