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EC 1.11.1.13 Details
EC number
1.11.1.13
Accepted name
manganese peroxidase
Reaction
2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
Other name(s)
peroxidase-M2, Mn-dependent (NADH-oxidizing) peroxidase
Systematic name
Mn(II):hydrogen-peroxide oxidoreductase
CAS registry number
114995-15-2
Comment
A hemoprotein. The enzyme from white rot basidiomycetes is involved in the oxidative degradation of lignin. The enzyme oxidizes a bound Mn2+ ion to Mn3+ in the presence of hydrogen peroxide. The product, Mn3+, is released from the active site in the presence of a chelator (mostly oxalate and malate) that stabilizes it against disproportionation to Mn2+ and insoluble Mn4+ [4]. The complexed Mn3+ ion can diffuse into the lignified cell wall, where it oxidizes phenolic components of lignin and other organic substrates [1]. It is inactive with veratryl alcohol or nonphenolic substrates.
History
created 1992
EC Tree
1.12.1.1 created 1965, deleted 1972