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EC 1.14.99.58 Details
EC number
1.14.99.58
Accepted name
heme oxygenase (biliverdin-IX-β and δ-forming)
Reaction
(1) protoheme + 3 reduced acceptor + 3 O2 = biliverdin-IX-δ + CO + Fe2+ + 3 acceptor + 3 H2O;;(2) protoheme + 3 reduced acceptor + 3 O2 = biliverdin-IX-β + CO + Fe2+ + 3 acceptor + 3 H2O
Other name(s)
pigA (gene name)
Systematic name
protoheme,donor:oxygen oxidoreductase (biliverdin-IX-β and δ-forming)
Comment
The enzyme, characterized from the bacterium Pseudomonas aeruginosa, differs from EC 1.14.15.20, heme oxygenase (biliverdin-producing, ferredoxin), in that the heme substrate is rotated by approximately 110 degrees within the active site, resulting in cleavage at a different part of the ring. It forms a mixture of about 70% biliverdin-IX-δ and 30% biliverdin-IX-β.
History
created 2017
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